The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas
Articolo
Data di Pubblicazione:
2013
Citazione:
The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas / M. Locatelli, S. Ferrero, F. Martinelli Boneschi, L. Boiocchi, M. Zavanone, S. Maria Gaini, L. Bello, S. Valentino, E. Barbati, M. Nebuloni, A. Mantovani, C. Garlanda. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 260:1-2(2013 Jul 15), pp. 99-106.
Abstract:
Inflammation is a component of glioma microenvironment. PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation. In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cancer-associated inflammation; Glioma; Immunohistochemistry; Macrophage; PTX3
Elenco autori:
M. Locatelli, S. Ferrero, F. Martinelli Boneschi, L. Boiocchi, M. Zavanone, S. Maria Gaini, L. Bello, S. Valentino, E. Barbati, M. Nebuloni, A. Mantovani, C. Garlanda
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