Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines
Articolo
Data di Pubblicazione:
2013
Citazione:
Stereoselective metal-free catalytic synthesis of chiral trifluoromethyl aryl and alkyl amines / A. Genoni, M. Benaglia, E. Massolo, S. Rossi. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 49:75(2013), pp. 8365-8367. [10.1039/c3cc43821j]
Abstract:
The enantioselective organocatalytic reduction of trifluoromethyl aryl and alkyl ketoimines afforded the corresponding fluorinated amines with high chemical and stereochemical efficiency. The Lewis base catalyzed reaction with trichlorosilane led to chiral products with a trifluoromethyl group directly linked to the newly generated stereocenter typically in >90% yield and up to 98% e.e.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
enantioselective reduction; hydrogenation; trichlorosilane; imines; access; esters
Elenco autori:
A. Genoni, M. Benaglia, E. Massolo, S. Rossi
Link alla scheda completa: