Prognostic value of multidetector computed tomography coronary angiography in diabetes : excellent long-term prognosis in patients with normal coronary arteries
Articolo
Data di Pubblicazione:
2013
Citazione:
Prognostic value of multidetector computed tomography coronary angiography in diabetes : excellent long-term prognosis in patients with normal coronary arteries / D. Andreini, G. Pontone, S. Mushtaq, E. Bertella, E. Conte, A. Baggiano, F. Veglia, P. Agostoni, A. Annoni, A. Formenti, P. Montorsi, G. Ballerini, A.L. Bartorelli, C. Fiorentini, M. Pepi. - In: DIABETES CARE. - ISSN 0149-5992. - 36:7(2013 Jul), pp. 1834-1841.
Abstract:
OBJECTIVE: To assess the prognostic role of multidetector computed tomography coronary angiography (MDCT-CA) in patients with diabetes with suspected coronary artery disease (CAD). Use of MDCT-CA is increasing in patients with suspected CAD. However, data supporting its prognostic value in patients with diabetes are limited. RESEARCH DESIGN AND METHODS: Between January 2006 and September 2007, 429 consecutive diabetic patients were prospectively studied with MDCT-CA for detecting the presence and assessing the extent of CAD (disease extension and coronary plaque cores). Patients were classified according to the presence of normal coronary arteries and nonobstructive (<50%) and obstructive (≥50%) coronary lesions. The composite rates of hard cardiac events (cardiac death, nonfatal myocardial infarction, unstable angina) and all ardiac events (including revascularization) were the end points of the study. RESULTS: Twenty-four patients were excluded because MDCT-CA data were not able to be interpreted. Of the remaining 405 patients, clinical follow-up (mean 62 ± 9 months) was obtained in 390 (98%). Multivariate analysis showed that predictors of hard and all events were obstructive CAD, three-vessel CAD, and left main coronary artery (LMCA) disease. Cumulative event-free survival was 100% for hard and all events in patients with normal coronary arteries, 78% for hard events and 56% for all events in patients with nonobstructive CAD, and 60% for hard events and 16% for all events in patients with obstructive CAD. Three-vessel CAD and LMCA disease were associated with a higher rate of hard cardiac events. CONCLUSIONS: MDCT-CA provides long-term prognostic information for patients with diabetes with suspected CAD, showing excellent prognosis when there is no evidence of atherosclerosis and allowing risk stratification when CAD is present.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Andreini, G. Pontone, S. Mushtaq, E. Bertella, E. Conte, A. Baggiano, F. Veglia, P. Agostoni, A. Annoni, A. Formenti, P. Montorsi, G. Ballerini, A.L. Bartorelli, C. Fiorentini, M. Pepi
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