Continuous-flow stereoselective organocatalyzed Diels-Alder reactions in a chiral catalytic "homemade" HPLC column
Articolo
Data di Pubblicazione:
2013
Citazione:
Continuous-flow stereoselective organocatalyzed Diels-Alder reactions in a chiral catalytic "homemade" HPLC column / V. Chiroli, M. Benaglia, F. Cozzi, A. Puglisi, R. Annunziata, G. Celentano. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 15:14(2013), pp. 3590-3593. [10.1021/ol401390z]
Abstract:
Continuous-flow organocatalyzed Diels-Alder reactions have been performed with excellent enantioselectivity for the first time in a chiral "homemade" HPLC column, packed with silica on which a MacMillan catalyst has been supported by a straightforward immobilization procedure. The versatility of the system was also proven by running with the same column continuous-flow stereoselective reactions with three different substrates, showing that the catalytic reactor may efficiently work in continuo for more than 150 h; the regeneration of the HPLC column was also demonstrated, allowing to further extend the activity of the reactor to more than 300 operating hours.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
organic-synthesis; highly efficient; silyl ehers; aldehydes; reactors; cycloaddition; technology; strategies; chemistry; batch
Elenco autori:
V. Chiroli, M. Benaglia, F. Cozzi, A. Puglisi, R. Annunziata, G. Celentano
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