A randomized trial of long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria
Articolo
Data di Pubblicazione:
2006
Citazione:
A randomized trial of long-chain polyunsaturated fatty acid supplementation in infants with phenylketonuria / C. Agostoni, A. Harvie, D.L. McCulloch, C. Demellweek, F. Cockburn, M. Giovannini, G. Murray, R.A. Harkness, E. Riva. - In: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. - ISSN 0012-1622. - 48:3(2006 Mar), pp. 207-212. [10.1017/S0012162206000442]
Abstract:
Forty-two infants (20 males, 22 females) with classical phenylketonuria (PKU) entered a prospective, double-blind, randomized study to investigate the effects on biochemical and physiological outcomes of a phenylalanine-free infant formula containing a fat blend supplemented with the long-chain polyunsaturated fatty acids (LC-PUFA), docosahexaenoic acid (DHA, C22:6 n-3), and arachidonic acid (AA, C20:4 n-6). Between entry and 20 weeks (entry and 1y) of age, median DHA levels in erythrocyte membrane phospholipids decreased by 15% (22%) in the LC-PUFA supplemented group (n=21) and by 61% (64%) in the control group (p<0.001; n=18). A dietary supply of LC-PUFA in infants with PKU prevents the decline in DHA levels associated with a diet supplying minimal sources of LC-PUFA. DHA status in turn, independent of diet, may influence the maturation of the visual system in infants with PKU.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
visual-evoked potentials; term infants; docosahexaenoic acid; breast-milk; children; diet; recommendations; acuity; VEP
Elenco autori:
C. Agostoni, A. Harvie, D.L. Mcculloch, C. Demellweek, F. Cockburn, M. Giovannini, G. Murray, R.A. Harkness, E. Riva
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