Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors

The synthesis of phenylene-ethynylene rods and their use as rigid spacers is described. Alternation of a Sonogashira reaction and
silyl group cleavage was used to obtain rigid spacers with even and odd numbers of phenylene units. Preliminary applications of
these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer
proved greatly beneficial for the inhibitory potency