Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors
Articolo
Data di Pubblicazione:
2013
Citazione:
Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors / F. Pertici, N. Varga, A. van Duijn, M. Rey-Carrizo, A. Bernardi, R.J. Pieters. - In: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1860-5397. - 9(2013), pp. 215-222. [10.3762/bjoc.9.25]
Abstract:
The synthesis of phenylene-ethynylene rods and their use as rigid spacers is described. Alternation of a Sonogashira reaction and
silyl group cleavage was used to obtain rigid spacers with even and odd numbers of phenylene units. Preliminary applications of
these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer
proved greatly beneficial for the inhibitory potency
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
LecA inhibition; Multivalent carbohydrates; Phenylene ethynylene; Rigid spacers; Sonogashira reaction
Elenco autori:
F. Pertici, N. Varga, A. van Duijn, M. Rey Carrizo, A. Bernardi, R.J. Pieters
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