Antiretroviral therapy during pregnancy

- Treatment with zidovudine has led to a fall in the mother-to-child HIV transmission during pregnancy and the first few weeks of neonatal life. - Ongoing trials are assessing the preventive efficacy of two-drug and three-drug antiretroviral regimens in this setting. - Pending the results of these studies, treatment with zidovudine is recommended for all HIV-infected pregnant women. - Current therapeutic strategies may lead to the prescription or continuation of multidrug antiretroviral regimens for seropositive pregnant women. - Available information on the possible adverse effects of antiretroviral drugs on the pregnant woman, fetus and child are limited. - Two reports propose similar guidelines for the management of seropositive pregnant women and their children during the first weeks of life.