Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease
Articolo
Data di Pubblicazione:
1995
Citazione:
Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease / R.W. Mahley, B.P. Nathan, S. Bellosta, R.E. Pitas. - In: CURRENT OPINION IN LIPIDOLOGY. - ISSN 0957-9672. - 6:2(1995 Apr), pp. 86-91.
Abstract:
Apolipoproteins E3 and E4 exert differential effects on neuronal growth in vitro. Apolipoprotein E3 supports neurite extension, whereas apolipoprotein E4 does not. These isoform-specific effects may influence the stability of the cytoskeleton and may account for the association of the apolipoprotein E4 isoform with the pathogenesis of Alzheimer's disease.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cytoskeleton ; Apolipoprotein E4 ; Neurons ; Humans ; Alzheimer Disease ; Apolipoproteins E ; Apolipoprotein E3
Elenco autori:
R.W. Mahley, B.P. Nathan, S. Bellosta, R.E. Pitas
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