Data di Pubblicazione:
1996
Citazione:
Factor V (Arg 506-->Gln) mutation in young survivors of myocardial infarction / D. Ardissino, F. Peyvandi, P.A. Merlini, E. Colombi, P.M. Mannucci. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - 75:5(1996), pp. 701-702.
Abstract:
Many young patients with venous thromboembolic disease are partially resistant to the anticoagulant action of activated protein C as a result of factor V (Arg506 → Gln) mutation. The frequency of this mutation in young patients with arterial thrombotic diseases, such as myocardial infarction, is less well established. We studied 100 young patients with myocardial infarction and 100 age- and sex-matched controls. One patient (1%; 95% CL 0.05-6.2) and two controls (2%; 95% CL 0.3-7.7) were heterozygotes for the mutation; there was no homozygote in either group. Hence, premature myocardial infarction is not associated with heterozygosity for factor V (Arg506 → Gln) mutation.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. Ardissino, F. Peyvandi, P.A. Merlini, E. Colombi, P.M. Mannucci
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