Data di Pubblicazione:
1984
Citazione:
Phorbol ester-induced changes in human leukemic pre-B lines / N. Sacchi, T.V. LeBien, S. Trost, D. Breviario, F.J. Bollum. - In: CELLULAR IMMUNOLOGY. - ISSN 0008-8749. - 84:1(1984 Mar), pp. 65-73.
Abstract:
The genomic analysis of four non-T-leukemic lines NALM-1, KM-3, NALL-1, and NALM-16 shows a rearranged configuration of the immunoglobulin mu chain genes, indicating that they represent early B stages of differentiation. The differentiative potential of these pre-B cell lines was tested using the phorbol ester tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA). Phenotypic changes in the immunological marker profile (induction of BA-1 and BA-2 antigens) are observed, presumably reflecting events occurring in precursor B cells. However, no maturation to immunoglobulin mu chain production could be obtained. The limited maturation can be explained on the basis of possible aberrant mu chain gene rearrangements, or other mechanisms of a regulatory nature, preventing the transcription and/or the translation of rearranged mu chain genes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
leukemia, lymphoid ; tetradecanoylphorbol acetate ; humans ; antigens, neoplasm ; cell differentiation ; neprilysin ; B-lymphocytes ; leukemia ; phorbols ; immunoglobulin mu-Chains ; stem cells ; cell line ; cell transformation, neoplastic
Elenco autori:
N. Sacchi, T.V. LeBien, S. Trost, D. Breviario, F.J. Bollum
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