Effect of hypolipidemic and hypoglycemic drugs on ethanol induced hypertriglyceridemia in rats

An experimental model of hypertriglyceridemia induced by subacute ethanol administration was developed in rats. A four day schedule of administration induced a 50-100% increase of serum triglycerides, without changes in cholesterol levels. Drugs effective on lipid or glucose metabolism were tested in this model. Hypoglycemic sulphonylureas, nicotinic acid, clofibrate, and the new hypolipidemic agent : diethylamide of beta-benzalbutyric acid (C11) proved to be effective agents in controlling ethanol induced hypertriglyceridemia. The activity of C11 was also confirmed in an ethanol induced hypertriglyceridemia in human volunteers.