Impact of rufloxacin and ciprofloxacin on the intestinal microflora in a germ-free mice model
Articolo
Data di Pubblicazione:
1995
Citazione:
Impact of rufloxacin and ciprofloxacin on the intestinal microflora in a
germ-free mice model / M.R. Gismondo, L. Drago, A. Lombardi, C. Fassina, M. Cesana. - In: CHEMOTHERAPY. - ISSN 0009-3157. - 41:4(1995 Jul), pp. 281-288.
Abstract:
The impact of rufloxacin and ciprofloxacin on faecal microflora was investigated
in an experimental germ-free mice model into which human gastrointestinal flora
was introduced and stabilized. Animals received oral doses of 10, 40 or 80 mg
rufloxacin/kg, 30 or 60 mg ciprofloxacin/kg once daily for 10 days, or no
treatment. Microflora was studied before, during and 1 week after treatment. No
significant effect ( < 2 log reduction, p > 0.05) on aerobic microflora was
observed after rufloxacin as compared to controls, except for a marked decrease
in enterobacteria and a slight decrease in enterococci, staphylococci and
anaerobes at the highest dose. Both doses of ciprofloxacin significantly reduced
enterobacteria and clostridia, while the lower dose slightly reduced peptococci,
bifidobacteria and eubacteria. The depression of the intestinal ecosystem was
reversible, except for enterobacteria at the higher ciprofloxacin dose. No
bacterial resistance was detected after either treatment.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Faecal microflora; Germ-free mice model; Rufloxacin
Elenco autori:
M.R. Gismondo, L. Drago, A. Lombardi, C. Fassina, M. Cesana
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