Data di Pubblicazione:
2008
Citazione:
Carotid intima media thickness as marker of atherosclerosis: results of the IMPROVE study / E. Tremoli, D. Baldassarre, R. Paoletti, R. Rauramaa, K. Nyyssönen, U. de Faire, A. Hamsten, A.J. Smit, E. Mannarino, P. Giral, E. Grossi. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 9:1(2008), pp. 213-213. ((Intervento presentato al 77. convegno EUROPEAN ATHEROSCLEROSIS SOCIETY (EAS) CONGRESS tenutosi a Istanbul, Turkey nel 2008.
Abstract:
The intima-media thickness (IMT) of carotid arteries, measured by high resolution
B-mode ultrasound has been proposed as an useful surrogate
marker of atherosclerosis in carotid arteries and in other vascular regions.
IMT is a good predictor of new myocardial infarction and it has been shown
to be influenced by drugs known to reduce cardiovascular events. In a
longitudinal - observational study, we have shown that the integrated use of
VRFs included into the Framingham risk score and ultrasonic measurements
of carotid IMT significantly increase their capacity to predict cardiovascular
events in patients at low/intermediate risk. The integration of carotid IMT
with non conventional VRFs (gene polymorphisms. oxidative burden, psyco
or socioeconomic aspects etc. ) may further optimize the stratification of
patient risk. Another important carotid ultrasonic variable that may have
predictive capacity, alone or when integrated with conventional or non
conventional risk factors, is the progression of carotid IMT. A prospective,
multicenter, longitudinal, long-term, observational study (The IMPROVE
study) is currently ongoing. It aims to investigate the capacity of both cross
sectional carotid IMT and overall IMT-progression to predict alone, or after
integration with both conventional and non conventional VRF, the rate of
new vascular events in an European population classified at high risk of
cardiovascular disease for the presence of at least 3 VRFs. The patients’
enrolment ended in April 2005 and a total of 3711 patients were recruited
in 5 European countries (1095 in ltaly, 504 in France and 2140 in northern
Europe).
Funding: Supported by European Union (IMPROVE: QLGI-CT-2002-
00896)
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
E. Tremoli, D. Baldassarre, R. Paoletti, R. Rauramaa, K. Nyyssönen, U. de Faire, A. Hamsten, A.J. Smit, E. Mannarino, P. Giral, E. Grossi
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