Data di Pubblicazione:
1996
Citazione:
Fatty acid metabolism in phenylketonuria / M. Giovannini, C. Agostoni, G. Biasucci, A. Rottoli, D. Luotti, S. Trojan, E. Riva. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - 155:Suppl 1(1996 Jul), pp. S132-S135.
Abstract:
Children treated for phenylketonuria (PKU) have a low intake of whole animal foods. Consequently, the dietary intake of long-chain polyunsaturated fatty acids (PUFA) is just a few milligrams per day, mostly represented by arachidonic acid (AA). In a consecutive series of studies, we assessed in treated PKU children their long-chain PUFA status, the AA-related eicosanoid synthesis and the effects of specific PUFA supplementations. We found that the good compliance with the dietary regimen negatively influences the long-chain PUFA status and serum eicosanoid release from platelets. Supplementation with either marine or blackcurrant oils modifies the long-chain PUFA status of PKU children without approaching the fatty acid pattern of a healthy control population. Good-compliant PKU patients have diet-related, low levels of circulating long-chain PUFA, whose clinical and functional consequences deserve further investigation. The effects of dietary supplementations with long-chain PUFA of both the n-6 and n-3 series should be carefully evaluated.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Infant; Fatty Acids, Unsaturated; Eicosanoids; Humans; Child; Phenylketonurias; Adolescent; Male; Female; Child, Preschool
Elenco autori:
M. Giovannini, C. Agostoni, G. Biasucci, A. Rottoli, D. Luotti, S. Trojan, E. Riva
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