Models for measuring hepatic glucose production from labelled IVGTT

In the line of the minimal modelling strategy, we present various modelling attempts to measure hepatic glucose production during a labelled intravenous glucose tolerance test (labelled IVGTT). We propose a physiological model which allows to reconstruct by deconvolution a profile of hepatic glucose production which is more reliable than those obtained with simpler models. The model presented incorporates the most recent information on the influence of insulin on glucose kinetics and allows recovery of a more physiological prediction of hepatic response during the IVGTT.