Synthesis of bis-(3,5)pyrazolophanes via double cycloadditive macrocyclisation

Double cycloadditive macrocyclisation of bis-hydrazonoyl chlorides 5 were performed with bis-allyl ethers 9 and 10, bis-vinyl ether 14 and bis-proparayl ether 18. The title compounds having a 18-, 19-, 22- or 24- membered ring annulated to the pyrazole units were obtained with good overall yield. (C) 2003 Elsevier Ltd. All rights reserved.