Rapid quantitation of cocaine and benzoylecgonine in urine by "on column" capillary gas chromatography after "Extrelut" extraction

Cocaine (I) [50-36-2] and its principal metabolite in man, benzoylecgonine [519-09-5], were detd. in urine by on column capillary gas chromatog. equipped with an NP detector. Isopropylbenzoylecgonine was used as the internal std. The extn. procedure was carried out with Extrelut. CH2N2 was utilized for derivatizing benzoylecgonine. The procedure was applied to a no. of urine samples received from a quality control program; the relative errors were 11.7% and 7.5% for I and benzoylecgonine, resp.