MODEL STUDIES FOR PREDICTING THE DIASTEREOSELECTIVITY IN THE CONDENSATION OF ALDEHYDES WITH ZINC AND COPPER-COMPLEXES OF AMINO-ACID DERIVATIVES .1. ANALYSIS AND REALIZATION OF THE MODELS

The asymmetric synthesis of beta-hydroxy-alpha-amino acids with good stereochemical selectivity represents a highly interesting synthetic goal. The possibility of predicting the stereochemical outcome of such preparation gives rise to the opportunity to direct synthetic efforts toward a well-defined objective. A model study on the role played, in this respect, by transition metal containing complexes is described. Four different models are considered and their construction is thoroughly examined.