Stereoselective adenylate deaminase (5 '-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5 '-alkyl substituted adenosines : A comparison with the action of adenosine deaminase (ADA)

Academic Article
Publication Date:
2004
Citation:
Stereoselective adenylate deaminase (5 '-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5 '-alkyl substituted adenosines : A comparison with the action of adenosine deaminase (ADA) / P.Ciuffreda, A. Loseto, E. Santaniello. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 15:2(2004), pp. 203-206. [10.1016/j.tetasy.2003.11.007]
abstract:
The enzymes adenylate deaminase (AMPDA) and adenosine deaminase (ADA) are able to catalyze the stereoselective hydrolytic deamination of (5'R,S)-methyl-2',3'-isopropylidene adenosine, but the 5'-butyl analog is a substrate only for AMPDA, which stereospecifically converts the (5'S)-isomer to the corresponding inosine derivative.
IRIS type:
01 - Articolo su periodico
Keywords:
INOSINE DERIVATIVES; ANALOGS
List of contributors:
Authors of the University:
Link to information sheet:
https://air.unimi.it/handle/2434/5221

Research Areas

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Settore BIO/10 - Biochimica