Stereoselective adenylate deaminase (5 '-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5 '-alkyl substituted adenosines : A comparison with the action of adenosine deaminase (ADA)

Articolo
Data di Pubblicazione:
2004
Citazione:
Stereoselective adenylate deaminase (5 '-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5 '-alkyl substituted adenosines : A comparison with the action of adenosine deaminase (ADA) / P.Ciuffreda, A. Loseto, E. Santaniello. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 15:2(2004), pp. 203-206. [10.1016/j.tetasy.2003.11.007]
Abstract:
The enzymes adenylate deaminase (AMPDA) and adenosine deaminase (ADA) are able to catalyze the stereoselective hydrolytic deamination of (5'R,S)-methyl-2',3'-isopropylidene adenosine, but the 5'-butyl analog is a substrate only for AMPDA, which stereospecifically converts the (5'S)-isomer to the corresponding inosine derivative.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
INOSINE DERIVATIVES; ANALOGS
Elenco autori:
P.Ciuffreda, A. Loseto, E. Santaniello
Autori di Ateneo:
CIUFFREDA PIERANGELA ( autore )
Link alla scheda completa:
https://air.unimi.it/handle/2434/5221

Aree Di Ricerca

Settori


Settore BIO/10 - Biochimica