[Quinolizidine derivatives with antimicrobial activity]

Thirty quinolizidinyl derivatives, together with two dialkylaminoalkyl analogues, were tested at concentration up to 160 mg/l for antimicrobial activity against 17 microrganisms, including gram-positive and gram-negative strains, Mycobac, tuberculosis, Trichom, vaginalis, fungi and yeasts. The most common activity found is that against Mycobac, tuberculosis, followed by that against gram-positive strains; several compounds [(I a), (I b), (I c), (II a), (III a), (VIII e), (XIX e), (XXI e)] exhibit a good or a very high level of activity. Concerning the gram-negative bacteria, activity is found only against Escherichia coli and is random and usually slight, as is that against fungi, yeasts and protozoa. Compounds (I a), (III a) and (XXI e) are of interest for their high activity and for their broad spectrum of activity, while compound (X e) is peculiar for its selectivity against Mycobac. tuberculosis.