Effects of Lactobacillus salivarius LS01 (DSM 22775) treatment on adult atopic dermatitis : a randomized placebo-controlled study
Articolo
Data di Pubblicazione:
2011
Citazione:
Effects of Lactobacillus salivarius LS01 (DSM 22775) treatment on adult atopic
dermatitis : a randomized placebo-controlled study / L. Drago, E. Iemoli, V. Rodighiero, L. Nicola, E. De Vecchi, S. Piconi. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 24:4(2011 Oct), pp. 1037-1048.
Abstract:
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by
xerosis, pruritus and eczema. The role of probiotics in the prevention and the
treatment of AD have been extensively studied in children with controversial
results while there are few studies on an adult population. The aim of this
randomized, double-blind, placebo-controlled study is to evaluate the clinical
efficacy of the intake of a probiotic strain (Lactobacillus salivarius LS01) in
the treatment of adult patients with AD. A group of 38 patients was treated with
probiotics or placebo (maltodextrin) for 16 weeks. The study was performed from
January (T0) to May, 2009 (T16). The assessment of efficacy was based on change
in SCORAD (SCORing Atopic Dermatitis) index, dermatology life quality index
(DLQI) improvement, cytokine production by PBMCs and ability to modify faecal
microbial flora. No significant adverse events were recorded during the study.
Patients treated with probiotics showed a statistically improvement of both
clinical parameters (SCORAD p<0.0001 and DLQI p= 0.021) at the end of
treatment (T16) compared with the placebo group. Furthermore, after four months
of treatment there was a significant reduction of Th1 cytokines (IL-12+IFNgamma)
(p= 0.03) and Th1/Th2 ratio (IL-12+IFNgamma/IL-4+IL-5) (p= 0.019) only in
placebo-treated patients. A statistically relevant decrease of staphylococci in
faeces of the probiotictreated group was also observed at the end of treatment.
In our study, the administration of L. salivarius LS01 was well tolerated and was
associated with a significant improvement of clinical manifestation and QoL. This
probiotic strain could have an important role in modulating Th1/Th2 cytokine
profiles and could be considered as an important adjunctive therapy in the
treatment of adult AD.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Drago, E. Iemoli, V. Rodighiero, L. Nicola, E. De Vecchi, S. Piconi
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