Modificazioni del ritmo bulbo-pontino indotte da platelet activating factor (PAF)

In 14 anaesthetized (Thiopental-sodium mg 15/kg iv) and tracheostomized pigs were evaluated the respiratory and circulatory responses evocated by PAF (25-50 ng/kg iv). PAF caused an increase in pulmonary arterial pressure, systemic hypotension, decrease in compliance (Crs) and increase in respiratory resistances. The decrease in Crs modified the VT/TI relationship showin the vagal activity on respiratory centres. Therefore our results show the PAF, acting on vagal afferences, modifies the bulbo-pontine activity.