Effetti della PGF2alfa sul diaframma nel maiale neonato

The EMG of costal and crural parts of diaphragm has been evaluated in 6 anaesthetized (Thiopental-sodium mg 15/kg i.v.) and tracheostomized newborn pigs. The EMG has been evaluated in control conditions and after PGF2alpha administration (mg 0.15-0.20/kg i.v.) The experiments were performed also after bilateral vagotomy. Our results showed an inhibitory vagal mechanism regulating the diaphragmatic EMG. This mechanism may be modified by PGF2alpha that induces a postinspiratory diaphragmatic activity. PGF2alpha after vagotomy did not cause significant changes. One could conclude that a reflex vagal mechanism is present and the diaphragmatic response to PGF2alpha is vagal dependent.