A FACILE SYNTHESIS OF PENTADEUTERATED DOMIODOL (2-IODOMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE) FROM GLYCEROL-1,1,2,3,3-D(5)
Articolo
Data di Pubblicazione:
1994
Citazione:
A FACILE SYNTHESIS OF PENTADEUTERATED DOMIODOL (2-IODOMETHYL-4-HYDROXYMETHYL-1,3-DIOXOLANE) FROM GLYCEROL-1,1,2,3,3-D(5) / P. FERRABOSCHI, P. GRISENTI, E. SANTANIELLO. - In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. - ISSN 0362-4803. - 34:3(1994), pp. 303-306.
Abstract:
The acid catalyzed reaction of glycerol-d5 with bromoacetaldehyde dimethyl acetal affords the corresponding 2-bromomethyl-4-hydroxymethyl-1,3-dioxolane, which was treated with lithium iodide in 2-butanone to afford the pentadeuterated domiodol 1 in high isotopic purity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
deuterium; domiodol; mucolytic drug; synthesis
Elenco autori:
P. FERRABOSCHI, P. GRISENTI, E. SANTANIELLO
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