Resolution of amines with isopropylidene glycerol hydrogen phthalate

The hydrogen phthalate of isopropylidene glycerol has been recently described as an efficient resolving agent of 1-arylethylamines. In order to gain more information on its versatility and to develop a rationale which accounts for its effectiveness, further 1-arylethylamines and other racemic amines were subjected to the same resolution process. A preliminary qualitative analysis of the results reported herein allows to identify some structural features of the aminic substrates conditioning the feasibility of the resolution.