Cloning and molecular characterization of three Ubiquitin Fusion Degradation 1 (Ufd1) ortholog genes from Xenopus laevis, Gallus gallus and Drosophila melanogaster
Articolo
Data di Pubblicazione:
2001
Citazione:
Cloning and molecular characterization of three Ubiquitin Fusion Degradation 1 (Ufd1) ortholog genes from Xenopus laevis, Gallus gallus and Drosophila melanogaster / A. Ratti, F. Amati, M. Bozzali, E. Conti, F. Sangiuolo, M. Berloco, G. Palumbo, A. Botta, A. Pizzuti, G. Novelli, B. Dallapiccola. - In: CYTOGENETICS AND CELL GENETICS. - ISSN 0301-0171. - 92:3-4(2001), pp. 279-282.
Abstract:
The yeast ubiquitin fusion degradation 1 (Ufd1) protein is involved in a degradation pathway for ubiquitin fused products. The human ortholog gene (UFD1-like, UFD1L) is deleted in patients affected by the DiGeorge/velocardiofacial syndromes. We report the cloning of UFD1L orthologs from Drosophila melanogaster (dufd1l), Xenopus laevis and Gallus gallus. The 1,125-bp Drosophila cDNA encodes a protein of 316 amino acids, showing 60% identity with the human and murine proteins. The identity to the G. gallus, X. laevis, C. elegans and S. cerevisiae proteins is 95%, 83%, 32%, and 36%, respectively. Northern expression data in Drosophila indicate that dufd1l is expressed through embryonic, larval and pupal development, as well as in the adult fly.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Ratti, F. Amati, M. Bozzali, E. Conti, F. Sangiuolo, M. Berloco, G. Palumbo, A. Botta, A. Pizzuti, G. Novelli, B. Dallapiccola
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