Stereocontrolled reduction of an oxazepinohexahydroindolo[2,3-a]quinolizine derivative: asymmetric total synthesis of (+)-tacamonine

Efficient, stereocontrolled total synthesis of the title compound is described. starting from enantiopure intermediates. A key step was the diastereoselective catalytic hydrogenation of a pentacyclic oxazepinohexahydroindolo[2,3-a]quinolizine derivative. (C) 2001 Elsevier Science Ltd. All rights reserved.