Data di Pubblicazione:
1999
Citazione:
Novel reverse-turn mimics inhibit farnesyl transferase / R. Liu, D. Dong, R. Sherlock, H. Nestler, C.M.A. Gennari, A. Mielgo, C. Scolastico. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 9:6(1999), pp. 847-852.
Abstract:
Reverse-turn inducing bicyclic lactams were incorporated into the substrate sequence recognized by farnesyl transferase to create inhibitors of RAS farnesylation. While the free peptides did not show any effect on the farnesylation, their Fmoc-protected counterparts impede the transformation of RAS with IC50's in the low micromolar range. (C) 1999 Elsevier Science Ltd. All rights reserved.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Liu, D. Dong, R. Sherlock, H. Nestler, C.M.A. Gennari, A. Mielgo, C. Scolastico
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