Prevention of local relapses and new localisations of oral leukoplakias with the synthetic retinoid fenretinide (4-HPR). Preliminary results
Articolo
Data di Pubblicazione:
1992
Citazione:
Prevention of local relapses and new
localisations of oral leukoplakias with the synthetic retinoid fenretinide (4-HPR). Preliminary results / F. Chiesa, N. Tradati, M. Marazza, N. Rossi, P. Boracchi, L. Mariani, M. Clerici, F. Formelli, L. Barzan, A. Carrassi. - In: EUROPEAN JOURNAL OF CANCER. PART B, ORAL ONCOLOGY. - ISSN 0964-1955. - 28B:2(1992 Oct), pp. 97-102. [10.1016/0964-1955(92)90035-Y]
Abstract:
This paper analyses preliminary results of a randomised chemoprevention trial in patients surgically treated for oral leukoplakia started in 1988 at the Istituto Nazionale Tumori of Milan with the synthetic retinoid N-(4-hydroxyphenyl)-retinamide (4-HPR). To date 115 patients have been randomised, after surgical excision of oral leukoplakia, to receive 200 mg 4-HPR daily for 52 weeks versus no intervention. 80 patients completed the 1-year intervention, 41 in the control group and 39 in the 4-HPR group. During this period 12 local relapses or new lesions occurred in the control group and three in the 4-HPR group. Only 5 patients interrupted the intervention because of toxicity. No impaired dark adaptation was observed. It is concluded that 4-HPR is well tolerated and seems efficacious in preventing relapses and new localisations during the treatment period. This promising trend needs further confirmation.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
F. Chiesa, N. Tradati, M. Marazza, N. Rossi, P. Boracchi, L. Mariani, M. Clerici, F. Formelli, L. Barzan, A. Carrassi
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