Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells
Articolo
Data di Pubblicazione:
2011
Citazione:
Multinucleated giant cells with an osteoclast phenotype derived from caprine
peripheral blood mononuclear cells / G. Pisoni, P. D’Amelio, F. Sassi, G. Manarolla, L. Scaccabarozzi, C. Locatelli, N. Mazzocchi, M. Baruscotti, D. DiFrancesco, P. Moroni. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 189:3(2011 Sep), pp. 361-363. [10.1016/j.tvjl.2010.07.016]
Abstract:
Formation of multinucleated giant cells (MGCs) by macrophage fusion is a typical cytopathic effect of lentiviral replication in caprine monocytes and MGC formation from cultured caprine peripheral blood mononuclear cells (PBMCs) has been considered to be diagnostic for small ruminant lentivirus (SRLV) infection. In this study, formation of MGCs was observed after 7–14 days when PBMCs were cultured from healthy goats free from SRLV infection. These MGCs expressed tartrate-resistant acid phosphatase, calcitonin receptor, integrin aVb3, cathepsin K and matrix metalloproteinase 9 and were able to resorb
bone in vitro in the absence of RANKL and macrophage colony stimulating factor, consistent with an osteoclast phenotype.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Caprine ; multinucleated giant cells ;
peripheral blood mononuclear cells ; osteoclast
Elenco autori:
G. Pisoni, P. D’Amelio, F. Sassi, G. Manarolla, L. Scaccabarozzi, C. Locatelli, N. Mazzocchi, M. Baruscotti, D. DiFrancesco, P. Moroni
Link alla scheda completa: