Data di Pubblicazione:
2010
Citazione:
Genetic analysis of small ruminant lentiviruses following lactogenic transmission / G. Pisoni, G. Bertoni, G. Manarolla, H.R. Vogt, L.M. Scaccabarozzi, C. Locatelli, P. Moroni. - In: VIROLOGY. - ISSN 0042-6822. - 407:1(2010), pp. 91-99. [10.1016/j.virol.2010.08.004]
Abstract:
Lactogenic transmission plays an important role in the biology of lentiviruses such as HIV and SIV or the small
ruminant lentiviruses (SRLV). In thisworkwe analyzed the characteristics of viruses that goats, naturally infected
with two strains of SRLV, transmitted to their kids. The spectrumof viral genotypes transmitted was broader and
the efficiency of transmission greater compared to their human and simian counterparts. The newly described
A10 subgroup of SRLVwas more efficiently transmitted than the B1 genotype. The analysis of a particular stretch
of the envelope glycoprotein encompassing a potential neutralizing epitope revealed that, as in SIV, the
transmitted viruses were positively charged in this region, but, in contrast to SIV, they tended to lack a
glycosylation site that might protect against antibody neutralization. We conclude that the physiology of the
ruminant neonatal intestine, which permits the adsorption of infected maternal cells, shaped the evolution of
these particular lentiviruses that represent a valid model of lactogenic lentivirus transmission.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Goat ; Small ruminant lentivirus ; Colostrum ; Milk ; Transmission ; Lactogenic transmission ; Genotype ; Lentivirus ; Caprine arthritis encephalitis virus ; Maedi–Visna virus
Elenco autori:
G. Pisoni, G. Bertoni, G. Manarolla, H.R. Vogt, L.M. Scaccabarozzi, C. Locatelli, P. Moroni
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