p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features
Articolo
Data di Pubblicazione:
2011
Citazione:
p53 status identifies two subgroups of triple-negative breast cancers with distinct biological features / E. Biganzoli, D. Coradini, F. Ambrogi, J. M. Garibaldi, P. Lisboa, D. Soria, A. R. Green, M. Pedriali, M. Piantelli, P. Querzoli, R. Demicheli, P. Boracchi. - In: JAPANESE JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0368-2811. - 41:2(2011), pp. 172-179.
Abstract:
Objective: Despite the clinical similarities triple-negative and basal-like breast cancer are not synonymous. Indeed, not all basal-like cancers are negative for estrogen receptor, progesterone receptor and HER2 expression while triple-negative also encompasses other cancer types. P53 protein appears heterogeneously expressed in triple-negative breast cancers, suggesting that it may be associated with specific biological subgroups with a different outcome. Methods: We comparatively analyzed p53 expression in triple-negative tumors from two independent breast cancer case series (633 cases from the University of Ferrara and 1076 cases from the University of Nottingham). Results: In both case series, p53 protein expression was able to subdivide the triple-negative cases into two distinct subsets consistent with a different outcome. In fact, triple-negative patients with a p53 expressing tumor showed worse overall and event-free survival. Conclusions: The immunohistochemical evaluation of p53 expression may help in taming the currently stormy relationship between pathological (triple-negative tumors) and biological (basal breast cancers) classifications and in selecting patient subgroups with different biological features providing a potentially powerful prognostic contribution in triple-negative breast cancers.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
breast cancer; triple-negative; prognosis; biological marker
Elenco autori:
E. Biganzoli, D. Coradini, F. Ambrogi, J. M. Garibaldi, P. Lisboa, D. Soria, A. R. Green, M. Pedriali, M. Piantelli, P. Querzoli, R. Demicheli, P. Boracchi
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