Poly(ethylene-glycol)-based Fluorinated Esters: a Readily Available Entry for Novel 19F-MRI agents
Articolo
Data di Pubblicazione:
2011
Citazione:
Poly(ethylene-glycol)-based Fluorinated Esters: a Readily Available Entry for Novel 19F-MRI agents / S. Rossi, M. Benaglia, M.A. Ortenzi, E. Micotti, C. Perego, M.G. De Simoni. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 52:49(2011), pp. 6581-6583.
Abstract:
Readily available, low cost, hydrosoluble poly(ethylene-glycol) derivatives of 2-(trifluoromethyl)-3,3,3-trifluoro-propanoic acid were easily synthesized and their properties as MRI agents are preliminarily investigated. Two novel polymers, of 2356 Da and 756 Da, respectively, both showing a single 19F signal at NMR in deuterated chloroform and D2O were fully characterized; both compounds were shown to be soluble in water. However when experiments of in vitro MR imaging were conducted a clear imaging was obtained only with the sample of 756 MW, pointing at the importance of the fluorine content of the carrier.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Rossi, M. Benaglia, M.A. Ortenzi, E. Micotti, C. Perego, M.G. De Simoni
Link alla scheda completa: