Le ricerche sull’acido solfidrico (H2S) nella prospettiva di nuovi interventi farmacologici

Hydrogen sulphide (H2S) is gaseous transmitter that the results of an intensive research of these last years adduces good reason for its role in different pathophysiological processes. The generation of H2S takes place in various mammalian cells from L-cysteine primarily via two key enzymes, cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS). The organ specific expression regulation of both CSE and CBS has been defined, and evidence is accumulating to demonstrate that inhibitors of H2S or therapeutic H2S-donors exert significant effects in various animal models of inflammation, reperfusion injury, gastric mucosal blood flow regulation, and many other. This article has the aim to describe the biofunctional properties of H2S and to prospect the potential therapeutic implications of this mediator principally in inflammation and cardiovascular pathology