Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model
Articolo
Data di Pubblicazione:
2005
Citazione:
Measurement of selective effect of insulin on glucose disposal from labeled glucose oral test minimal model / C. Dalla Man, A. Caumo, R. Basu, R. Rizza, G. Toffolo, C. Cobelli. - In: AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM. - ISSN 0193-1849. - 289:5(2005 Nov), pp. E909-E914.
Abstract:
The oral glucose minimal model (OMM) measures insulin sensitivity (S(I)) and the glucose rate of appearance (R(a)) of ingested glucose in the presence of physiological changes of insulin and glucose concentrations. However, S(I) of OMM measures the overall effect of insulin on glucose utilization and glucose production. In this study we show that, by adding a tracer to the oral dose, e.g., of a meal, and by using the labeled version of OMM, OMM* to interpret the data, one can measure the selective effect of insulin on glucose disposal, S(I)*. Eighty-eight individuals underwent both a triple-tracer meal with the tracer-to-tracee clamp technique, providing a model-independent reference of the R(a) of ingested glucose (R(a meal)(ref)) and an insulin-modified labeled intravenous glucose tolerance test (IVGTT*). We show that OMM* provides not only a reliable means of tracing the R(a) of ingested glucose (R(a meal)) but also accurately measures S(I)*. We do so by comparing OMM* R(a meal) with the model-independent R(a meal)(ref) provided by the tracer-to-tracee clamp technique, while OMM* S(I)* is compared with both S(I)(* ref), obtained by using as known input R(a meal)(ref), and with S(I)* measured during IVGTT*.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Glucose utilization; Insulin action; Intravenous glucose tolerance test; Oral glucose tolerance test; Tracer-to-tracee activity clamp
Elenco autori:
C. Dalla Man, A. Caumo, R. Basu, R. Rizza, G. Toffolo, C. Cobelli
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