Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies
Articolo
Data di Pubblicazione:
2011
Citazione:
Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies / C. Fattorusso, M. Persico, N. Basilico, D. Taramelli, E. Fattorusso, F. Scala, O. Taglialatela Scafati. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 19:1(2011 Jan 01), pp. 312-320. [10.1016/j.bmc.2010.11.014]
Abstract:
In our search for new antimalarial agents inspired by natural products, we describe herein the synthesis, the evaluation of in vitro antiplasmodial activity, and the SAR studies for a series of endoperoxide antimalarials based on the plakortin scaffold. These simplified analogues are characterized by: (i) a 3,6-dihydro-1,2-dioxin ring or a 1,2-dioxane ring disubstituted at C-4 and C-5; (ii) a pentyl substituent at C-6 ('western' alkyl side chain) and they have been prepared from commercially available material using simple reactions.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Fattorusso, M. Persico, N. Basilico, D. Taramelli, E. Fattorusso, F. Scala, O. Taglialatela Scafati
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