Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes
Articolo
Data di Pubblicazione:
2011
Citazione:
Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes / L. Rizzi, M. Braschi, M. Colombo, N. Vaiana, G. Tibolla, G.D. Norata, A. Catapano, S. Romeo, D. Prosperi. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 9:8(2011 Apr 21), pp. 2899-2905.
Abstract:
Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
drug; delivery; fluorescence; derivatives; copolymers; liposomes; therapy; systems; water
Elenco autori:
L. Rizzi, M. Braschi, M. Colombo, N. Vaiana, G. Tibolla, G.D. Norata, A. Catapano, S. Romeo, D. Prosperi
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