Synthesis and Anti-Helicobacter pylori Activity of 4-(Coumarin-3-yl)thiazol-2-ylhydrazone Derivatives

A novel class of coumarin-thiazole conjugated systems (1–31) were synthesized by Hantzsch condensation between a-bromo-3-acetyl coumarin and several thiosemicarbazone intermediates. This scaffold was also evaluated for selective antibacterial activity against 20 isolates of H. pylori clinical strains,including four metronidazole resistant ones.