Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes
Articolo
Data di Pubblicazione:
2024
Citazione:
Investigation into the Anti-Acne Effects of Castanea sativa Mill Leaf and Its Pure Ellagitannin Castalagin in HaCaT Cells Infected with Cutibacterium acnes / S. Piazza, G. Martinelli, N. Maranta, C. Pozzoli, M. Fumagalli, V. Nicolaci, E. Sonzogni, L. Colombo, E. Sangiovanni, M. Dell’Agli. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 25:9(2024 Apr 27), pp. 4764.1-4764.14. [10.3390/ijms25094764]
Abstract:
Acne vulgaris is a prevalent skin disorder affecting many young individuals, marked by keratinization, inflammation, seborrhea, and colonization by Cutibacterium acnes (C. acnes). Ellagitannins, known for their antibacterial and anti-inflammatory properties, have not been widely studied for their anti-acne effects. Chestnut (Castanea sativa Mill., C. sativa), a rich ellagitannin source, including castalagin whose acne-related bioactivity was previously unexplored, was investigated in this study. The research assessed the effect of C. sativa leaf extract and castalagin on human keratinocytes (HaCaT) infected with C. acnes, finding that both inhibited IL-8 and IL-6 release at concentrations below 25 g/mL. The action mechanism was linked to NF- B inhibition, without AP-1 involvement. Furthermore, the extract displayed anti-biofilm properties and reduced CK-10 expression, indicating a potential role in mitigating inflammation, bacterial colonization, and keratosis. Castalagin’s bioactivity mirrored the extract’s effects, notably in IL-8 inhibition, NF- B inhibition, and biofilm formation at low M levels. Other polyphenols, such as flavonol glycosides identified via LC-MS, might also contribute to the extract’s biological activities. This study is the first to explore ellagitannins’ potential in treating acne, offering insights for developing chestnut-based anti-acne
treatments pending future in vivo studies.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
acne; keratinocyte; inflammation; Castanea sativa Mill.; ellagitannins
Elenco autori:
S. Piazza, G. Martinelli, N. Maranta, C. Pozzoli, M. Fumagalli, V. Nicolaci, E. Sonzogni, L. Colombo, E. Sangiovanni, M. Dell’Agli
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