Paraoxonase gene mutations in amyotrophic lateral sclerosis

Articolo
Data di Pubblicazione:
2010
Citazione:
Paraoxonase gene mutations in amyotrophic lateral sclerosis / N. Ticozzi, A.L. Leclerc, P. Keagle, J.D. Glass, A.M. Wills, M. van Blitterswijk, D.A. Bosco, I. Rodriguez Leyva, C. Gellera, A. Ratti, F. Taroni, D.M. McKenna Yasek, P.C. Sapp, V. Silani, C.E. Furlong, R.H. Brown Jr, J.E. Landers. - In: ANNALS OF NEUROLOGY. - ISSN 0364-5134. - 68:1(2010), pp. 102-107. [10.1002/ana.21993]
Abstract:
Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
low-density-lipotrotein; sporadic ALS; cluster polymorphisms; colorectal adenomas; rare variants; PON1; susceptibility; protein; identification; promoter
Elenco autori:
N. Ticozzi, A.L. Leclerc, P. Keagle, J.D. Glass, A.M. Wills, M. van Blitterswijk, D.A. Bosco, I. Rodriguez Leyva, C. Gellera, A. Ratti, F. Taroni, D.M. McKenna Yasek, P.C. Sapp, V. Silani, C.E. Furlong, R.H. Brown Jr, J.E. Landers
Autori di Ateneo:
RATTI ANTONIA ( autore )
TICOZZI NICOLA ( autore )
Link alla scheda completa:
https://air.unimi.it/handle/2434/145295

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