muma, An R Package for Metabolomics Univariate and Multivariate Statistical Analysis

Metabolomics, similarly to other high-throughput “-omics” techniques, generates large arrays of data, whose
analysis and interpretation can be difficult and not always straightforward. Several software for the detailed metabolomics
statistical analysis are available, however there is a lack of simple protocols guiding the user through a standard statistical
analysis of the data.
Herein we present “muma”, an R package providing a simple step-wise pipeline for metabolomics univariate and multi-
variate statistical analyses. Based on published statistical algorithms and techniques, muma provides user-friendly tools
for the whole process of data analysis, ranging from data imputation and preprocessing, to dataset exploration, to data in-
terpretation through unsupervised/supervised multivariate and/or univariate techniques. Of note, specific tools and graph-
ics aiding the explanation of statistical outcomes have been developed. Finally, a section dedicated to metabolomics data
interpretation has been implemented, providing specific techniques for molecular assignments and biochemical interpreta-
tion of metabolic patterns.
muma is a free, user-friendly and versatile tool suite tailored to assist the user in the interpretation of metabolomics data in
the identification of biomarkers and in the analysis of metabolic patterns