Miniaturized enantioselective tubular devices for the electromechanical wireless separation of chiral analytes
Articolo
Data di Pubblicazione:
2024
Citazione:
Miniaturized enantioselective tubular devices for the electromechanical wireless separation of chiral analytes / S. Grecchi, G. Salinas, R. Cirilli, T. Benincori, S. Ghirardi, A. Kuhn, S. Arnaboldi. - In: CHEM. - ISSN 2451-9294. - 10:2(2024 Feb 08), pp. 660-674. [10.1016/j.chempr.2023.11.001]
Abstract:
Chirality plays a crucial role in different research fields, ranging from fundamental physico-chemistry to applied aspects in materials sci- ence and medicine. In this context, enantioselective loading and pumping of chiral analytes for analysis, separation, and cargo deliv- ery applications is an interesting scientific challenge. Herein, we introduce artificial chiral soft electromechanical pumps based on a bi-layer film built up by electrodepositing polypyrrole and an inher- ently chiral conducting oligomer at its internal surface. The enantio- selective device can be driven by bipolar electrochemistry to act as a pump, allowing the selective loading and separation of different chi- ral analytes injected as pure enantiomers and in racemic form (i.e., doxorubicin, a chemotherapy drug, limonene, carvone, and a chiral ferrocene). The synergy between wireless electromechanical actua- tion and inherent enantiodiscrimination features makes these actu- ators excellent candidates for the controlled handling of chiral mol- ecules in the frame of potential applications ranging from analysis to drug delivery.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
bipolar electrochemistry; chiral wireless separation; chirality; conducting polymers; high enantiomeric purity; miniaturized systems; multi-analyte separation; SDG3: Good health and well-being; SDG6: Clean water and sanitation; SDG9: Industry, innovation, and infrastructure; tubular chiral devices
Elenco autori:
S. Grecchi, G. Salinas, R. Cirilli, T. Benincori, S. Ghirardi, A. Kuhn, S. Arnaboldi
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