Sequential base-promoted annulation/palladium-catalyzed domino 1,5-enyne arylation and vinylation of alpha-propargylaminohydrazones

The sequential base-promoted annulation/palladium catalyzed cascade 1,5-enyne arylation and vinylation cascade reactions of easily accessible alpha-propargylaminohydrazones represent a simple and efficient method for the stereoselective preparation of (Z)-6-arylidene/vinylidene-6a-methyl,1,5,6a-terahydro-2H-pyrrolo[3,2-c]pyrazol-3-ones.