Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability

Articolo
Data di Pubblicazione:
2021
Citazione:
Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability / C. Borsari, E. Keles, A. Treyer, M. De Pascale, P. Hebeisen, M. Hamburger, M.P. Wymann. - In: RSC MEDICINAL CHEMISTRY. - ISSN 2632-8682. - 12:4(2021 Apr), pp. 579-583. [10.1039/d0md00408a]
Abstract:
Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound11showed predicted BBB permeability in a MDCK-MDR1 permeabilityin vitroassay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurological disorders.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Borsari, E. Keles, A. Treyer, M. De Pascale, P. Hebeisen, M. Hamburger, M.P. Wymann
Autori di Ateneo:
BORSARI CHIARA ( autore )
Link alla scheda completa:
https://air.unimi.it/handle/2434/1016354
Link al Full Text:

Aree Di Ricerca

Settori


Settore CHIM/08 - Chimica Farmaceutica