Data di Pubblicazione:
2009
Citazione:
Acid-Base Properties of Poly(amidoamine)s / E. Ranucci, P. Ferruti, E. Lattanzio, A.G. Manfredi, M. Rossi, P.R. Mussini, F. Chiellini, C. Bartoli. - In: JOURNAL OF POLYMER SCIENCE. PART A, POLYMER CHEMISTRY. - ISSN 0887-624X. - 47:24(2009), pp. 6977-6991. [10.1002/pola.23737]
Abstract:
Polyamidoamines (PAAs) represent a family of degradable polymers carrying
ter-amine groups in the polymer backbone, which behave as polyelectrolytes in
aqueous solutions. Many relevant properties of PAAs, including the ability to interact
with components of the biological environments, such as nucleic acids, proteins, and
living cells, are strongly dependent on their acid-base properties, hence on their ionization
state in different biological districts. In this article, the protonation constants
of a series of PAAs have been precisely determined by electrochemical techniques in
order to build up a homogeneous library containing both the protonation constants
and the average distribution of the charged species, hence the net average charge as
a function of pH. Moreover, correlations between chemical and cytotoxicity, have
been attempted.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Biocompatible and biodegradable polymers; Electrochemistry; Poly(amidoamine)s; Polyelectrolytes; Water-soluble polymers
Elenco autori:
E. Ranucci, P. Ferruti, E. Lattanzio, A.G. Manfredi, M. Rossi, P.R. Mussini, F. Chiellini, C. Bartoli
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