Research on Emerging Medical radionuclides from the X-sections (REMIX): The Accelerator-based Production of 47Sc, 149Tb, 152Tb, 155Tb and 161Tb

The cyclotron-based production of medical radionuclides is one of the research activities carried out at INFN-LNL in the framework of the interdisciplinary project LARAMED (LAboratory of RAdionuclides for MEDicine). Since the LARAMED bunkers and ancillary laboratories are currently under completion, experiments on nuclear cross section measurements are carried out in collaboration with the ARRONAX facility (Nantes, France). The REMIX project, funded by INFN in the years 2021/2023, is focused on the production of 47Sc, 149Tb, 152Tb, 155Tb and 161Tb radionuclides, whose decay characteristics make them suitable for medical applications. This work will outline the main results achieved withing the REMIX collaboration, that is organized in the following Work Packages (WP): WP1. Target manufacturing (49Ti, 50Ti and 155Gd2O3) and characterization (resp. S. Cisternino); WP2. Nuclear cross section (XS) measurements with 49Ti and 50Ti targets for 47Sc production (resp. L. Mou); WP3. Nuclear XS measurements with natDy, 159Tb and natEu targets for xxTb production (resp. S. Manenti); WP4. Nuclear XS modeling for 47Sc and 155Tb production (resp. L. Canton and A. Fontana); WP5. Dosimetric calculations for 47Sc- and xxTb-labelled radiopharmaceuticals (resp. L. Meléndez-Alafort and L. De Nardo); WP6. 155Tb Thick Target Yield (TTY) measurements (resp. P. Martini); WP7. Apparatus design and realization for irradiation tests with the LARAMED beam-line (resp. G. Sciacca).