Data di Pubblicazione:
2023
Citazione:
A convenient protocol for a zinc-catalysed synthesis of electron-poor indoles / F. Medici, F. Montinari, E. Donato, L. Raimondi, M. Benaglia. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 116:(2023 Feb 17), pp. 154340.1-154340.4. [10.1016/j.tetlet.2023.154340]
Abstract:
A convenient catalytic protocol for the synthesis of electron-poor indoles was envisioned. A cyclisation reaction of electron-deficient 2-(alkynyl)-anilines, catalysed by Zn(II) salts, was successfully developed and applied to the synthesis of an API precursor. A two-step one-pot procedure starting from aniline derivatives was successfully developed. The use of a readily available, non-noble metal further enhanced the value of the protocol.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Indole; Cyclisation; Zinc; API precursor; Alkynyl group;
Elenco autori:
F. Medici, F. Montinari, E. Donato, L. Raimondi, M. Benaglia
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