Paper radiochromatography for evaluation of radiochemical purity and stability of [186gRe]Re- HEDP in biological samples after human administration
Articolo
Data di Pubblicazione:
2008
Citazione:
Paper radiochromatography for evaluation of radiochemical purity and stability of [186gRe]Re- HEDP in biological samples after human administration / S. Ridone, M.L. Bonardi, F. Groppi, A. Martinotti, Z.B. Alfassi. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 277:1(2008 Jul), pp. 117-123. [10.1007/s10967-008-0718-3]
Abstract:
[186gRe]Re-HEDP is a radiopharmaceutical used for pain palliation in bone metastases from various primary tumors. The negatron emitter with = 357 keV 186gRe is suitable to irradiate cancer and inflammatory cells, but it needs labeling bis-phosphonates as vectors to reach target
tissue. Paper radiochromatography was used to evaluate the radiochemical purity of [186gRe]Re-HEDP in radiopharmaceutical solution as well as in biological samples (serum and urine) from treated patients, in order to follow bone-targeting and excretion. Following the activity concentration in each sample vs. time it is effective to elaborate a bio-kinetic model of the radiopharmaceutical and to optimize administration protocols.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
[186gRe]Re-HEDP ; radiopharmaceuticals ; pain palliation ; metabolic radiotherapy ; bio-kinetic model
Elenco autori:
S. Ridone, M.L. Bonardi, F. Groppi, A. Martinotti, Z.B. Alfassi
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